MA-Series: Mechanically-Agitated Bioreactor Systems
Mechanically Agitated (MA) systems are the most common and universal type of bioreactors available today. Our MA bioreactor is distinguished from other systems in terms of construction and design. Our modular design, PLC control system, and use of industry-standard materials & components result in durability, simple installation, straightforward use, and uncomplicated maintenance.
To meet a wide range of requirements, we carry a complete line of MA bioreactors that include sizes ranging from 1 to 14 liters for bench top and >30L for pilot or production plants; and for a diversity of applications such as microbial, plant, insect, animal, and human cells, and for both adherent & suspension cell cultures. We also welcome the opportunity to partner with you in designing a completely customized MA system.
MA-010/015X
Six or Eight independent 1L mechanically agitated bioreactors on one common stainless steel bench sharing one 12" HMI color screen.
MA-100
Glass vessel with heating and cooling stainless steel jacketed bottom that utilizes water circulation system.
MA-150
Glass vessel with heating and cooling stainless steel jacketed bottom that utilizes water circulation system; also includes 4 rotameters for 4 gases.
MA-100X2 System with 10” HMI Screen
MA -100X4 System with 10” HMI Screen
MA-200/250: Custom Made to Order Pilot-Scale Systems (30+ Liter Size)
“We purchased Bioreactor Sciences’ (BRS) MA-150 in 2017 and it has been integral in scaling up production of our membrane protein. BRS’ MA-150 is Metaclipse’s first lab bioreactor and it has proven to be very reliable and intuitive to operate. Their customer service and technical support has been invaluable in assisting us with establishing our SOP for a fed-batch process in less than one month. This verified process has allowed us to successfully develop procedures to manufacture 2 proteins and 2 antibodies. I highly recommend it.”
-Swe, Senior Scientist, Metaclipse Therapeutics
“BioReactor Sciences' MA100 represents an excellent option for bench-scale bioreactor systems when ease-of-entry and fast batch turnaround times are required. With its Program and Setup features, industrial standard components, process automation and tune-ability, routine cultures are stable, robust, and relatively trouble-free compared to similarly or higher priced glass & stainless systems. The MA-100 is an excellent choice for those looking for an easy-to-use and dependable platform for small to medium microbial fermentation.”
-Kevin, Fermentation Specialist, Genesis Biosciences
Our MA system for microbial culture (MA-010,100 &200) and cell culture (MA-015,150 &250) are very similar. Our standard vessels are glass (<14L) or s/s (>40L) with s/s jacked vessels for water heating and cooling. Optionally we also provide vessels with water circulation coil for heating and cooling to reduce the total vessel weight. We also provide round bottom glass vessel with only heating pad for cell cultures which requires no cooling. The std vessel configuration and control system are nearly identical between both cell and microbial cultures except for the impeller type (microbial: Rushton impellers; cell culture: pitched blade or marine impeller), baffle (microbial: detachable baffle; cell culture: none) and gassing (microbial: 1 or 2 gasses, cell culture: 4 gasses). It is therefore very easy to convert our system from cell to microbial culture system. However it may be more complicated to do the other because of the gassing system.
Our MA systems can also easily be adopted for perfusion or continuous culture by simple modifications to be used as a Perfusion/Fixed Bed bioreactor [see more].
For flexibility and functionality, we recently developed a bench top control console, BioFlex, which can be applied for most of bench top single use or reusable vessels and applications including MA, AL, PF, BF.. [see more] .
Features
Industrial grade microprocessor
Clearly presented graphic user interface with HMI color touch panel and easy parameter adjustment
Trend display of up to 8 process values with variable display cycles for quick overview
Specially configured gassing systems for microbial and cell culture
Control of agitator speed, pH, DO*, temperature, foam, filling level, substrate addition, gas mixture and gas volume (optional with mass flow controller) *cascade control with agitation, oxygen, air, and head pressure.
Agitation system directly driven by detachable AC servo motor
Programmable setpoint change of all controllable parameters including pH, temperature, DO, feeding rates etc during the entire culturing process.
Battery-protected memory storage for vital parameters
Automated pH/DO calibration
Gas mixing: N2/O2/CO2/Air mixture (for cell culture); Air (for microbial culture or optional with Air/O2 ) with rotameter and ON/OFF control valve (std)
Four peristaltic pumps for each vessel: programmable for acid /base addition, defoaming, and/or feeding. Two additional pump outlets for external feeding option.
Communication protocol: two way RS485 and Ethernet interface for remote monitoring, control, and interface between user's computer in the lab, office or home and control console for data logging & remote operation
MA 010/015 and MA 100/150: Autoclave sterilization; MA 200/250 Sterilization -in-place.
[OPTIONAL] Mass flow and controller for gas control
[OPTIONAL] Redox potential measurement
[OPTIONAL] Turbidity measurement for optical density
[OPTIONAL] Load cell for nutrient feed
[OPTIONAL] Pressure control module for vessel head pressure control
One rotameter for air (std for microbial culture) and one additional rotameter with one on/off control valve for enriched O2 if MFC is not used (optional); or Four rotameters and controller for 4 gases (std for cell culture) if mass flow controllers are not used.
Applications
Microbial, plant, insect, and mammalian cells in batch, fed-batch, or continuous culture
Process development and manufacturing of vaccines, recombinant proteins, monoclonal antibodies, and stem cells.
Adherent or suspension cell cultures
